Shu-Ming Li

Shu-Ming Li

Prof. Dr. Shu-Ming Li

Pharmaceutical Biology and Biotechnology
Robert-Koch-Str. 4, 35037 Marburg
+49-6421 28 22461


Research Area

The main focus of Li lab is the functional genomics of secondary metabolites in microorganisms, especially in fungi of ascomycetes and bacteria of actinomycetes. The most interested substances are polyketides, cyclodipeptide derivatives and prenylated natural products.

Further research interests are chemoenzymatic biosynthesis and synthetic microbiological approaches for production of biologically active compounds.


synthetic microbiology
actinomycetes genetics
fungal genetics
site-directed mutagensis
biochemistry and enzymology
natural product biosynthesis
isolation and analysis of microbial metabolites
structural elucidation of low-molecular compounds

Recent Publications, Last 3 Years

1. Liao G, Mai P, Fan J, Zocher Z, Stehle T, Li S-M (2018) Complete decoration of the indolyl residue of tryptophan-containing cyclic dipeptides with geranyl moieties via protein engineering. Org Lett 20: 7201– 7205.

2. Liu J, Xie X, Li S-M (2019) Guanitrypmycin biosynthetic pathways imply cytochrome P450-mediated regio- and stereospecific guaninyl transfer reactions. Angew Chem Intern Ed 58: 11534-11540.

3. Fan J, Liao G, Kindinger F, Ludwig-Radtke L, Yin W-B, Li S-M (2019) Peniphenone and penilactone formation in Penicillium crustosum via 1,4-Michael additions of ortho-quinone methide from hydroxyclavatol to γ-butyrolactones from crustosic acid. J Amer Chem Soc 141: 4225–4229.

SYNMIKRO Young Researchers Groups

Almost all scientific members of SYNMIKRO are actively involved in DFG’s Collaborative Research Centers (Sonderforschungsbereiche), Research Training Groups (Graduiertenkollegs), or other Cooperative Research projects. Alongside performing adventurous experiments, and reporting excellent science, SYNMIKRO substantially promotes potential Young Research Group Leaders by constantly keeping its doors open to welcome and support Young Researchers planning to set up an Independent Research Group.
Our Young Research Groups