Roland Lill

Roland Lill

Prof. Dr. Roland Lill

Medicine / Institute for Cytobiology
Biochemistry / Cell biology
Robert-Koch-Straße 6, 35037 Marburg
+49-6421 28 66449


Research Area

The Lill group elucidates the molecular mechanisms underlying the biogenesis of iron-sulfur (Fe/S) proteins in eukaryotes. Fe/S proteins play important roles in, e.g., mitochondrial respiration, ribosomal protein translation, DNA synthesis and repair, and antiviral response. Eukaryotic Fe/S protein biogenesis involves more than 30 cellular proteins and its failure is associated with human disease. Mitochondrial Fe/S proteins require the iron-sulfur cluster assembly (ISC) machinery which was inherited from bacteria during evolution. Cytosolic and nuclear Fe/S protein maturation also depends on this machinery, yet additionally requires the mitochondrial ABC transporter Atm1 and the cytosolic iron-sulfur protein assembly (CIA) machinery.


Cell Biology
Mitochondrial diseases
ABC transporters
Yeast genetics
Human cell culture
Protein spectroscopy

Recent Publications, Last 3 Years

1. Lill, R. & Freibert, S.A. (2020). Mechanisms of mitochondrial iron-sulfur protein biogenesis. Annu. Rev. Biochem. 89, in press.

2. Stehling, O., Jeoung, J.H., Freibert, S.A., Paul, V.D., Bänfer, S., Niggemeyer, B., Rösser, R., Dobbek, H., & Lill, R. (2018). Function and crystal structure of the dimeric P-loop ATPase CFD1 coordinating an exposed [4Fe-4S] cluster for transfer to apoproteins. Proc. Natl. Acad. Sci. U.S.A. 115, E9085-E9094.

3. Freibert, S.A., Goldberg, A.V., Hacker, C., Molik, S., Dean, P., Williams, T.A., Nakjang, S., Long, S., Sendra, K., Bill, E., Heinz, E., Hirt, R.P., Lucocq, J.M., Embley, T.M., & Lill, R. (2017). Evolutionary conservation and in vitro reconstitution of microsporidian iron-sulfur cluster biosynthesis. Nat. Commun. 8, 13932.

SYNMIKRO Young Researchers Groups

Almost all scientific members of SYNMIKRO are actively involved in DFG’s Collaborative Research Centers (Sonderforschungsbereiche), Research Training Groups (Graduiertenkollegs), or other Cooperative Research projects. Alongside performing adventurous experiments, and reporting excellent science, SYNMIKRO substantially promotes potential Young Research Group Leaders by constantly keeping its doors open to welcome and support Young Researchers planning to set up an Independent Research Group.
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