Olalla Vázquez

Olalla Vázquez

Jun.-Prof. Dr. Olalla Vázquez

Department of Chemistry
Chemical Biology
Hans-Meerwein-Straße 4, 35032 Marburg
+49-6421-28 22745
olalla.vazquez@staff.uni-marburg.de

Research Area

Our young research group strive to develop innovative chemical biology tools based on our genuine ability to combine organic chemistry and biological approaches. This multidisciplinary approach is focused on the synthesis of novel photosensitive molecules capable of sensing biological processes, and remotely controlling the sophisticated cellular machinery behind relevant disease-related processes. We emphasize the use of molecular approaches to address essential biological questions.

Expertise

chemical biology
bioorganic chemistry
peptides and peptidomimetics
peptide nucleic acids
molecular switches
epigenetics
DNA binding
fluorescence
bioorthogonal reactions
photosensitizers

Recent Publications, Last 3 Years

1. Linden G, Zhang L, Pieck F, Linne U, Kosenkov D, Tonner R, Vázquez O (2019) Conditional singlet oxygen generation via DNA-targeted tetrazine bioorthogonal reaction. Angew Chem Int Ed Engl 58 12868-12873

2. Schulte L N, Heinrich B, Janga H, Schmeck B T, Vázquez O (2018) A far-red fluorescent DNA binder for interaction studies of live multidrug-resistant pathogens and host cells. Angew Chem Int Ed Engl 57 11564-11568

3. Albert L, Xu J, Wan R, Srinivasan V, Vázquez O (2017) Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia. Chem. Sci. 8 4612-4618

http://olallalab.org

SYNMIKRO Young Researchers Groups

Almost all scientific members of SYNMIKRO are actively involved in DFG’s Collaborative Research Centers (Sonderforschungsbereiche), Research Training Groups (Graduiertenkollegs), or other Cooperative Research projects. Alongside performing adventurous experiments, and reporting excellent science, SYNMIKRO substantially promotes potential Young Research Group Leaders by constantly keeping its doors open to welcome and support Young Researchers planning to set up an Independent Research Group.
Our Young Research Groups