Jan Schuller

Dr. Jan Michael Schuller

SYNMIKRO Research Center
CryoEM of molecular machines
Hans-Meerwein-Straße 6
35032 Marburg
+49-6421 28 22584

Research Area

The Schuller laboratory investigates the structure and function of macromolecular assemblies using structural biology, biochemistry and molecular biology. Our laboratory specializes in cryoEM single particle analysis. This method enables us not only to determine high-resolution structures of membrane-bound multiprotein complexes, but also to uncover their molecular dynamics, which is essential for understanding their biomolecular function. We are particularly interested. in biological systems that are responsible for biological carbon fixation, biological energy conversion and transport. Current topics of research are: (I) Prokaryotic Carbon concentration mechanism. (II) Thylakoid biogenesis and maintenance. (III) Carbon fixation and energy conservation in chemolithoautotrophic metabolism.

These biochemical pathways hold a wealth of opportunities for synthetic biology approaches that could be used to create improved microbes for the production of chemical compounds, to produce solar fuels and to sequester CO2 to combat global warming.


Cryo-EM single particle analysis
Structural Biology
Enzymatic mechanisms
CO2 Fixation
Anaerobic metabolism

Recent Publications

1. Redox-coupled proton pumping drives carbon concentration in the photosynthetic complex I. Schuller JM* #, Saura P#, Thiemann J#, Schuller SK, Gamiz-Hernandez AP, Kurisu G, Nowaczy* MM, Kaila VRI*. Nature Comm 2020 Jan 24;11(1):494.

2. Structural adaptations of photosynthetic complex I enable ferredoxin-dependent electron transfer. Schuller JM*, Birrell JA, Tanaka H, Konuma T, Wulfhorst H, Cox N, Schuller SK, Thiemann J, Lubitz W, Sétif P, Ikegami T, Engel BD, Kurisu *, Nowaczyk MM*. Science. 2019 Jan 18;363(6424):257-260

3. Structures of the cyanobacterial circadian oscillator frozen in a fully assembled state. Snijder J#, Schuller JM#, Wiegard A, Lössl P, Schmelling N, Axmann IM, Plitzko JM, Förster F, Heck AJ. Science. 2017 Mar 17;355(6330)

SYNMIKRO Young Researchers Groups

Almost all scientific members of SYNMIKRO are actively involved in DFG’s Collaborative Research Centers (Sonderforschungsbereiche), Research Training Groups (Graduiertenkollegs), or other Cooperative Research projects. Alongside performing adventurous experiments, and reporting excellent science, SYNMIKRO substantially promotes potential Young Research Group Leaders by constantly keeping its doors open to welcome and support Young Researchers planning to set up an Independent Research Group.
Our Young Research Groups