It is a pleasure to welcome Delia Casas Pastor from Spain as a new PhD student to our lab! Delia has a background in Biotechnology and received her Bachelor from the University of Salamanca in Spain. Subsquently, she received excellent training in bioinformatics and modeling approaches during her Masters' studies of Synthetic Biology at Newcastle University in the UK, and is now ready to dive into the Synthetic Biology of ECF sigma factors. Welcome Delia!
We are happy that Angelika Diehl chose our lab to work on her Master thesis in the upcoming months. Angelika is a biologist and very eager to expand her skillset by computational approaches, which she will use to study the interaction between ECF sigma factors and anti-sigma factors in closer detail. Welcome Angelika!
We warmly welcome Andre Sim from Messey University in New Zealand as a new PhD student to our lab! In his research Andre will focus on how the synthesis of the cell wall is coordinated with the global growth physiology of Bacillus subtilis.
We are happy to welcome Julia Manning from the University of Bath (UK) to our group! Julia studies Biochemistry and decided to join us for one year as a placement student. Her work on a quick and flexible toolkit for chromosomal integration of regulatory circuits in B. subtilis will be supported by the ERASMUS programme.
The focus of this review is the cell envelope stress response (CESR) of B. subtilis, and in particular the response to bacitracin challenge, which is now a well-studied case that serves as a paradigm. We take an “historical” point of view, which allows the reader to follow the development of the field, from a descriptive beginning, to a better and better understanding of the mechanisms, including the latest results from our labs. Read more here: Radeck et al., Curr. Genet., online first
Hannah just received an acceptance letter for a scholarship via the Cusanuswerk, which will fund her PhD studies on computational modelling of antibiotic resistance modules over the next 3 years - Congratulations Hannah!!!
In this year's selection symposium of the IMPRS-Mic graduate school we had a number of strong candidates and we are glad that one of the IMPRS-Mic scholarships went to Andre Sim from Messey University (New Zealand). Andre chose our lab as his place to be for his PhD studies and we are looking very much forward to having him here in Marburg from August onwards!
We are happy that Luis Oviedo from Sevilla (Spain) joins our lab as a research assistant! He will work on the development of a bioinformatic database and a corresponding web-interface to it. So welcome Luis!
Hooray - our next paper on the `Anatomy of the bacitracin resistance network in Bacillus subtilis' was accepted in Molecular Microbiology. In this piece we show that the resistance network against the antimicrobial peptide bacitracin is composed of multiple modules that feature active redundancy - a regulation strategy that activates the expression of additional protective layers only if other resistance modules fail. Check out the full story in Radeck et al., Mol. Microbiol. 100, 607-620.
Our paper on `Single-cell characterization of metabolic switching in the sugar phosphotransferase system (PTS) of Escherichia coli' was accepted and finally made it to the cover of Molecular Microbiology. Using a combination of experiment and theory we show in this paper that PTS sugar utilization involves not only switching between the sugars utilized but also switching between different utilization strategies. Find out more in Westermayer et al., Mol. Microbiol. 100, 472-485.