Georg Fritz

Georg Fritz

Dr. Georg Fritz

LOEWE-Zentrum für Synthetische Mikrobiologie
Quantitative and Computational Microbiology
Hans-Meerwein-Straße 6, 35032 Marburg
+49-6421 28 22582
georg.fritz@synmikro.uni-marburg.de

 

Research area


Microbial cells have evolved various ways in which they respond to changes in environmental conditions - frequently causing the adjustment of gene expression patterns. One focus of our research is to reverse-engineer the molecular mechanisms behind such natural gene regulation strategies and to provide model-driven hypotheses for the evolutionary consequences associated with them. For instance, by using a combination of theoretical and experimental methods we decipher some of the regulatory mechanisms behind stochastic phenomena in the expression of carbon utilization systems in Escherichia coli and study the dynamics and interconnections of cell envelope stress response systems in Bacillus subtilis.

In addition to our reverse-engineering efforts, our second major research focus is the forward design and implementation of small, well-defined synthetic circuits with novel functionalities. Based on the quantitative experimental characteristics of individual biological parts, we perform in silico simulations to explore the signal processing potential of those circuit modules. In doing so, our analysis serves as a theoretical guide for the optimal design of synthetic gene regulation strategies, which can ultimately be applied, for instance, to drive the heterologous expression of biosynthetic pathways. However, the success of implementing new functionalities into microbes is challenged by the inherent interconnectivity of virtually any compound within a living cell. Therefore, a central goal of our work is to better understand the context-dependence of synthetic biology building blocks. On a more general level, this will enable us to infer some of the design rules of bacterial gene regulation, which will be applied to construct “orthogonal”, i.e., context-independent, regulatory circuits.

 

SYNMIKRO Young Researchers Groups

Almost all scientific members of SYNMIKRO are actively involved in DFG’s Collaborative Research Centers (Sonderforschungsbereiche), Research Training Groups (Graduiertenkollegs), or other Cooperative Research projects. Alongside performing adventurous experiments, and reporting excellent science, SYNMIKRO substantially promotes potential Young Research Group Leaders by constantly keeping its doors open to welcome and support Young Researchers planning to set up an Independent Research Group.
Our Young Research Groups