Mohamed A. Marahiel

Mohamed A. Marahiel

Prof. Dr. Mohamed A. Marahiel

Chemistry
Biochemistry
Hans-Meerwein-Straße 4, 35032 Marburg
+49-6421 28 25722
marahiel@staff.uni-marburg.de
http://www.uni-marburg.de/fb15/ag-marahiel

 

Research area

We have in recent years gained many important insights into the biosynthesis of non-ribosomally synthesized biologically active secondary metabolites and, more recently, insights into the biosynthesis of ribosomal synthesized lassopeptides. In recent years, the metal homeostasis in the gram-positive model organism Bacillus subtilis was investigated.

 

Research project within SYNMIKRO

Within the scope of SYNMIKRO our group is working on expanding the biosynthetic potential of secondary metabolites and ribosomally synthesized peptides. Many peptidic secondary metabolites have relevant pharmacological properties, ranging from antibiotic to antitumor activities. Through the manipulation of secondary metabolite biosynthetic pathways we want to increase the structural diversity and thereby the spectrum of potential applications and properties of peptidic secondary metabolites. A recent example of successful manipulation is the integration of the RGD epitope into the lasso peptide microcin J25, transforming it into a potent integrin inhibitor.

In addition we are working on the analysis of Bacillus subtilis iron homeostasis, to deepen the fundamental understanding of this process as well as to identify and characterize potential antibiotic targets. A recent successful example was the characterization of the iron-sulfur-cluster biosynthesis in cooperation with the Lill group.

SYNMIKRO Young Researchers Groups

Almost all scientific members of SYNMIKRO are actively involved in DFG’s Collaborative Research Centers (Sonderforschungsbereiche), Research Training Groups (Graduiertenkollegs), or other Cooperative Research projects. Alongside performing adventurous experiments, and reporting excellent science, SYNMIKRO substantially promotes potential Young Research Group Leaders by constantly keeping its doors open to welcome and support Young Researchers planning to set up an Independent Research Group.
Our Young Research Groups